Synovial perfusion and synovial fluid solutes.

answer goes back to the cardinal signs of inflammation. The redness and heat of this state relate directly to increased local blood supply, and these critical findings cannot be examined systematically without accurate quantification of flow. Further, the imbalances of vascular permeability and tissue clearance that lead to tissue swelling cannot be evaluated usefully without an understanding of perfusion. Thus, disorders of synovial blood flow lie at the heart of clinical arthritis. If we are to understand articular inflammation and to quantify our management of it, it seems desirable and necessary to measure the synovial blood flow.